LDL cholesterol level: the difference between LDL and LDL cholesterol level; Is LDL-cholesterol truly ‘bad’ cholesterol? Is HDL-cholesterol protective? An in depth look at LDL cholesterol level and its physiological significance.
Get the 7 day Cholesterol-lowering program here: thecholesterolchallenge.com (use code 50%OFF for half price)
LDL cholesterol level under 100mg/dL. LDL vs LDL-cholesterol, cholesterol is NOT the problem, HDL is NOT good cholesterol and LDL is not ‘bad’. lipoproteins carry fat. lipoproteins: low density lipoprotein or LDL vs high-density lipoprotein or HDL. lab results: LDL-cholesterol level, not LDL. lipoproteins (LDL) carry cholesterol. LDL-cholesterol is cholesterol carried in LDL lipoproteins. LDL lipoproteins = cars. LDL-cholesterol = passengers
HDL-cholesterol = cholesterol traveling in HDL lipoproteins. add all cholesterol = Total cholesterol (lab results)
Triglycerides in lipoproteins. LDL vs LDL-cholesterol level. good cholesterol and bad cholesterol? is LDL-cholesterol ‘bad’? animals with high LDL-cholesterol level, people with high LDL-cholesterol level = heart disease. people with low LDL-cholesterol level are health freaks?
RCTs on LDL-cholesterol level: group with LDL-cholesterol level lowered has less heart disease. high LDL-cholesterol level is a problem. strong case that high LDL-cholesterol level is an issue
we have different levels of LDL-cholesterol. low ldl-cholesterol level from birth = less heart disease. ldl-cholesterol level not 100% in genes
high LDL-cholesterol level spells trouble. “no longer an ‘LDL-Cholesterol hypothesis’. increased LDL-Cholesterol level causal; lowering LDL particles reduces events”. “cholesterol-containing lipoproteins, particularly LDL cause CHD”
does high LDL-cholesterol level cause heart disease? main problem are lipoproteins, not LDL-cholesterol. “number of lipoprotein particles rather than cholesterol or triglycerides”
Heart disease caused by lipoproteins stuck in artery wall. lab results: LDL-cholesterol, triglycerides. apoB (carried by LDL) tells us number of lipoproteins
LDL-P (particles) = count of LDL lipoproteins. LDL lipoproteins = cause of heart disease. lab results: cholesterol… Is LDL-cholesterol level useless? for most people, more lipoproteins = more cholesterol, LDL-Cholesterol level = ok estimation
non-HDL cholesterol (Total cholesterol – HDL-cholesterol) = cholesterol not carried by HDL lipoproteins. if LDL-cholesterol level is good, chances are LDL particles are ok. lipoproteins carry cholesterol. too many lipoproteins cause heart disease, esp. LDL. LDL-Cholesterol gives idea of LDL lipoproteins
is HDL good? high HDL-cholesterol = less heart disease. hence good cholesterol. BUT raising HDL-cholesterol or genetically high HDL-cholesterol isn’t better
“simplistic hypothesis for HDL-cholesterol: increasing levels reduces CV events”. HDL not useless. HDL lipoproteins pull cholesterol from plaque. raising HDL-Cholesterol? people ask “how do I get my HDL higher” (they mean hdl-cholesterol, on lab results)
very high HDL-cholesterol level associated with higher risk? high LDL-Cholesterol + HDL-Cholesterol? is HDL-Cholesterol “bad”? good vs bad cholesterol doesn’t match evidence. LDL isn’t “bad”. We all have LDL and LDL-cholesterol. LDL-cholesterol like other parameters
for details on lowering cholesterol: thecholesterolchallenge.com (cholesterol-lowering menu)
video on lowering cholesterol with healthy foods. next video we’ll keep looking at cholesterol
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References:
https://www.ahajournals.org/doi/10.1161/01.ATV.20.4.1068
https://academic.oup.com/eurheartj/article/38/32/2459/3745109
https://academic.oup.com/eurheartj/advance-article/doi/10.1093/eurheartj/ehz962/5735221
https://academic.oup.com/eurheartj/article/41/1/111/5556353
https://www.nejm.org/doi/full/10.1056/nejmoa054013
https://bit.ly/2NiK5vQ
https://journals.plos.org/plosmedicine/article/file?id=10.1371/journal.pmed.1003062&type=printable
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4103514/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3070150/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4889017/
https://www.ahajournals.org/doi/10.1161/CIRCRESAHA.119.312617
https://www.sciencedirect.com/science/article/pii/S0140673612603122
Disclaimer: The contents of this video are for informational purposes only and are not intended to be medical advice, diagnosis, or treatment, nor to replace medical care. The information presented herein is accurate and conforms to the available scientific evidence to the best of the author’s knowledge as of the time of posting. Always seek the advice of your physician or other qualified health provider with any questions regarding any medical condition. Never disregard professional medical advice or delay seeking it because of information contained in Nutrition Made Simple!.
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Comments
Great content with a sufficiently nuanced explanation. I think if someone understands this they've got at least enough information to realise they don't need to listen to every new "cholesterol is great!" Or "cholesterol kills you!" headline they read. Thanks, as ever, for teaching people how to think about information.
OK, late comment but… Let me see if I got this right. Having high total lipoproteins will cause LDL lipoproteins to stick to your arteries? HDL lipoproteins unstick the LDL lipoproteins and transport them to the liver to be excreted from the body? They similarly transport the LDL lipoproteins out of the body before they have the chance to stick.
HDL lipoproteins should not be considered "good cholesterol" per se, but they do have good LDL unsticking and excretion qualities. Total cholesterol is a good gauge of cardiac risk. Thus, a healthy person should aim for having total cholesterol <= 200 while having a lower concentration of LDL and a higher concentration of HDL. That said, one would still need high enough levels of LDL to support healthy cellular function. Thus, abiding by the standard ranges identified on your blood test for LDL, HDL, triglycerides, and total cholesterol is a safe target and will promote good cardiac health and lower the risk of unnecessary cardiac events
Is this correct?
This video knocked it out of the park! This Doc is good!
how can someone reduce their particle count while keeping cholesterol levels the same?
I brought my LDL down to the optimal level using Lipitor. Does this mean that I can eat eggs without worrying?
I'm going to look into you cholesterol lowering diet plan. It better have bacon in it!
There must be a human lab where the scientists are doing all the experiments to impress us. Ha ha
Nice video sir
Like test measuring average 3 months value of blood dugar( Hba1C test), is there sny test available to measure average 3 months value of LDL in my blood sir? Pl reply
I didn't even get lab results, my Dr just said "your cholesterol levels are just above what we consider high. You can go on statins for the rest of your life now, or try and reduce your cholesterol with lifestyle changes, and we'll test again in a couple of months"
I chose lifestyle changes, and got retested a few months later. I then got a text saying "your blood test shows you could do with reducing your cholesterol. We advise another test in 12 months"
Australian here im confused
In a previous video you likened a CAC score at this age to Lung Cancer
Hey Doc, I’m a Portuguese American currently residing in Lisbon and hoping you can offer me some advice/reassurance as my cardio won’t see me until the 17th and I am terrified . At 35 I got a CAC test and I have a score of 10. As you can imagine I don’t know whom to trust or where to turn. I’ve stopped smoking, am eating exclusively veggies with the occasional sardinha. I’m doing some walking as well but I fear heavy exercise as when I walk up steep hills I fee some heartburn which I assume is probably a clogged artery. I would gladly pay for the cost of a visit… I just need some advice at this point I feel my life is over
Hi. I am 52 this year. A year ago I had test report as such: LDL 3.2 mmol/l, HDL 2.0; Triglyceride 1.1 and total cholesterol at 5.7mmol. I took 3 eggs a day since for a full year and this was the result:- LDL 3.8 mmol; HDL 1.5; Triglyceride 0.7 and total cholesterol remains 5.7 mmol. Can you comment on such reading?
This is confusing. At 8:05: "People with high HDL-C have less heart disease." But then, at 8:20, "People with genetically-high HDL-C weren't better off, either." I understand that raising it with drugs doesn't help, but the other part is contradictory.
I though total cholesterol was HDL + LDL + 20% triglycerides = total cholesterol. Incorrect?
I have to wait till monday to understand mine. My ldl chol is 120 and says high on the medical app it says its suppose to be at 0-99 and my cholesterol says it should be 100-199 and mine is at 209 😢 I dont know if its really bad.
I just had a blood test done and now i have low thyroid function and high hdl. I have to have another blood test done in 6 weeks but last july i ended up in a vascular ward with blood clotting in the internal and external jugular right side to base of skull (pet scan)and ct scans and a lot of blood test (factor 5 leiden is in the family, mother but i tested negative but told it could be a false negative due to heparin and clexain ) plus clotting to right side of heart duel pe’s and entire right subclavian. Am on xeralto 20 mg now plus telmistatan 40 mg. Blood pressure ok always around 130/85. Next blood test says for hdl cholesterol plus tsh and t4 if indicated , any suggestions on diet or anything you could recommend for a second opinion please, Thank you.
So nice to see this guy has largely abandoned all the YouTube tropes of choppy editing, and exaggerated facial expressions and hand gestures in his newer videos. His excessive use of those annoying tropes in this 3 yr old video was quite stark, to me. I honestly had trouble watching this old video. So glad he’s stopped using all the tropes in his newer videos. The newer videos tend to be more conversational and have much longer edits. So much easier to watch. Thank you to the presenter (sorry, forgot his name).
My hdl is 76. I am scared
If I ate dead animals I’d be dead by now.
Someone claimed that we are more and more certain with every well designed study that LDL cholesterol from meat can cause heart disease but the effect size is getting smaller and smaller since we exclude everytime another factor like smoking, lack of physical activity etc. Is this true? It seems at least plausible since the problem was always to eliminate factors and I can imagine that obesity etc. would significantly scew the numbers.